Xa sidibana nezixhobo zonyango, izitho ezenziweyo okanye izixhobo zokuhlinzwa, sihlala siqaphela ukuba zeziphi izinto ezenziwe ngazo. Ngapha koko, ukukhetha kwethu imathiriyeli kubalulekile. Irabha ye-Silicone sisixhobo esisetyenziswa ngokubanzi kwicandelo lezonyango, kwaye iimpawu zayo ezibalaseleyo ze-biocompatibility zifanele ukuphononongwa nzulu. Eli nqaku liza kuphonononga nzulu i-biocompatibility yerabha ye-silicone kunye nokusetyenziswa kwayo kwintsimi yezonyango.
Irabha ye-Silicone yinto ephezulu ye-molecular organic equlethe iibhondi ze-silicon kunye neebhondi zekhabhoni kwisakhiwo sayo sekhemikhali, ngoko kuthathwa njengento engabonakaliyo. Kwicandelo lezonyango, irabha ye-silicone isetyenziswa kakhulu ukwenza izixhobo ezahlukeneyo zonyango kunye nezixhobo zonyango, ezinje ngeendawo ezenziweyo, ii-pacemakers, iiprostheses zamabele, ii-catheters kunye ne-ventilators. Esinye sezizathu eziphambili zokuba irabha ye-silicone isetyenziswe ngokubanzi kukuhambelana kwayo okuhle kakhulu.
I-biocompatibility yerabha ye-silicone ngokuqhelekileyo ibhekisela kubume bentsebenziswano phakathi kwezinto kunye nezicubu zomntu, igazi kunye nolunye ulwelo lwe-biological. Phakathi kwazo, izibonakaliso eziqhelekileyo ziquka i-cytotoxicity, impendulo yokuvuvukala, ukuphendula komzimba kunye ne-thrombosis.
Okokuqala, i-cytotoxicity yerabha ye-silicone iphantsi kakhulu. Oku kuthetha ukuba xa irabha ye-silicone idibana neeseli zomntu, ayiyi kubangela nayiphi na imiphumo emibi kubo. Kunoko, iyakwazi ukusebenzisana kunye neeprotheyini zeseli kunye nokukhuthaza ukuvuselelwa kwezicubu kunye nokulungiswa ngokuzibophezela kubo. Esi siphumo senza irabha ye-silicone ibe yinto ebalulekileyo kwiinkalo ezininzi ze-biomedical.
Okwesibini, irabha ye-silicone nayo ayibangeli impendulo ebalulekileyo yokuvuvukala. Emzimbeni womntu, impendulo yokuvuvukala yindlela yokuzikhusela eqalwa xa umzimba wenzakala okanye usulelekile ukukhusela umzimba kumonakalo ongaphezulu. Nangona kunjalo, ukuba izinto ngokwazo zibangela impendulo yokuvuvukala, ayifanelekanga ukusetyenziswa kwintsimi yezonyango. Ngethamsanqa, irabha ye-silicone ine-reactivity ephantsi kakhulu yokukrala kwaye ke ayibangeli monakalo omkhulu kumzimba womntu.
Ukongeza kwi-cytotoxicity kunye nempendulo yokuvuvukala, irabha ye-silicone nayo iyakwazi ukunciphisa impendulo yomzimba. Emzimbeni womntu, i-immune system yindlela ekhusela umzimba kwiintsholongwane zangaphandle kunye nezinye izinto eziyingozi. Nangona kunjalo, xa izinto ezenziweyo zingena emzimbeni, amajoni omzimba anokuziqonda njengezinto zangaphandle kwaye aqalise ukusabela komzimba. Le mpendulo ye-immune inokubangela ukuvuvukala okungafunekiyo kunye nezinye iziphumo ezibi. Ngokwahlukileyo, impendulo ye-immune ye-rubber ye-silicone iphantsi kakhulu, oku kuthetha ukuba ingabakho emzimbeni womntu ixesha elide ngaphandle kokubangela nayiphi na impendulo yokuzivikela.
Ekugqibeleni, irabha ye-silicone nayo ineempawu ezichasene ne-thrombotic. I-Thrombosis sisifo esibangela ukuba igazi lijiye kwaye lenze amahlwili. Ukuba ihlwili legazi liyaphuka lize lihanjiswe kwezinye iindawo, linokubangela isifo sentliziyo, isifo sohlangothi, kunye nezinye iingxaki ezinzulu zempilo. I-rubber ye-silicone inokuthintela i-thrombosis kwaye ingasetyenziselwa kwizixhobo ezifana ne-valve yentliziyo eyenziweyo, ukukhusela ngokufanelekileyo iingxaki zempilo ezifana nesifo senhliziyo kunye ne-stroke.
Ngamafutshane, i-biocompatibility yerabha ye-silicone ihle kakhulu, eyenza ibe yinto ebalulekileyo kwintsimi yezonyango. Ngenxa ye-cytotoxicity ephantsi, i-reactivity ephantsi yokuvuvukala, i-immunoreactivity ephantsi kunye neempawu ezichasene ne-thrombotic, irabha ye-silicone inokusetyenziswa ngokubanzi kwimveliso yamalungu okwenziwa, izixhobo zonyango kunye nezixhobo zotyando, njl. njl., ukunceda abaguli bafumane iziphumo ezingcono zonyango kunye nomgangatho we ubomi.
Ixesha lokuposa: Jul-15-2024